First name: AURELIAN Surname: UDRISTIOIU Specialty: European Specialist in Laboratory Medicine Age: 58 Gender: Male Date of Birth: 05/11/1954 Citizenship: Romanian Home Address: Traian Street, No: 26, City: Targu-Jiu, Romania Telephone: 40723621414 Email Address: aurelianu2007@yahoo.com Reason for applying to work abroad: Passion for works of researches in onco-hematology field Available From (Month, Year): September / 2012
LANGUAGE SKILLS:
Language Level ENGLISH 5 ITALIAN 5 RUSSIAN 4 ARABIC 3
MEDICAL AUTHORITY REGISTRATIONS:
Medical Authority Registration Number License to practice in: EUROPEN UNION-EU Certificate of Conformity, Number: NO. VIII. d / 55001 / 19. 10. 2007 BUCHAREST, ROMANIA.
Name and address of the hospital: Emergency County Hospital TARGU-JIU,.Progresului Street No.18,Gorj, Postal Code:Zip 210218,Romania; Fax :00-40-253-210432 ;Phone :00-40-723621414, Romania.
- Manuscript 11-03-LM-U-MR-0052.R2/11/12/2011.
Journal of Medical Safety/September/2012, Tokio, Japan
Review of Applied Physics (RAP) Volume 2 Issue 1, March 2013; p-17-22 BC (Biochimica Clinica ), SS (Special Supplement), Volume 37, ISSN 0393-0564, Milan, Italy, 19-23 Mai 2013
Biophysical Journal, 2010. WRITEN BOOKS: 1.Aurelian Udristioiu. “Fitness Bike and Health”. Ed. Medicala 1990, Bucuresti. ISBN: 973-39-01105-9; Formatul 16/10 x 100; Nr pagini: 78.
2.Aurelian Udristioiu. “Bioenergetics of malign and normal cells” Ed. Academica Brancusi 2002, Targu Jiu, Bun de tipar, Bucuresti, Tipografia Everest 2001; ISBN 973 85342-6-7; Formatul 16/14 x 100; Nr. Pagini: 307.
3. Aurelian Udristioiu, Manole Cojocaru, Radu Iliescu., “Hematological and Metabolic Aspects from Laboratory Medicine" (ISBN 978-3-8473-0775-4). LAP LAMBERT Academic Publishing GmbH & Co. KG Heinrich-Böcking-Str. 6-8 , 66121, Saarbrücken, Germany, 2012.
4. Book title: Renal Diseases / Book 2 (ISBN 979-953-307-704-7). Chapter title: Variability of Biological Parameters in Blood Samples between Two Consecutive Schedules of Hemodyalsis Authors: Aurelian Udristioiu, Manole Cojocaru, Victor Dumitrascu, Daliborca Cristina Vlad, Alexandra Dana Maria Panait and Radu Iliescu, Publishing Group 2011. Volume 2, Issue 4 (JULY 2011) NATIONAL AND INTERNATIONAL AWARDS
- Aurelian Udristioiu. Anti-miocard Antibodies in Rheumatic Fever, Measured by Immunofluorescence, Medical Days, Craiova – May 1983. – Premium III Diploma. - Aurelian Udristioiu. International Travel Grant AACC: Winner/56-th Annual Meeting AACC, 08/25-29/2004, Los Angeles, California, USA. -Aurelian Udristioiu. International Travel Grant AACC, Winner/57-th Annual Meeting AACC, 07/24-28/2005, Orlando (FL), USA. - Aurelian Udristioiu. Award: Clinical Chemist`s Recognition Award/2007-2008 and Award/2009, AACC, Washington al Society, since 2008, Columbus, (OH), USA.. -Aurelian Udristioiu, ‘ Who is Who in Romania/2009’ -Romanian Personality in Book Enciclopedy -Aurelian Udristioiu. Award: Clinical Chemist`s Recognition Award/2007-2008 and Award/2009, AACC, Washington . - Aurelian Udristioiu, ‘ Who is Who in medical departments USA/ 2011-2012: Who's Who in Medicine and Healthcare 2011-2012 (8th Edition) ” MarquisWho'sWho” , 300 ConnellDrive, Suite 2000, Berkeley Heights, N0: 07922 USA 1-908-673-1000 , www.marquiswhoswho.com
The Role of the P-53 Gene and the p-53 Protein in the Oncogenesis of Non-Hodgkin Malignant Lymphomas Aurelian Udristioiu, MD, Fellow PhD, Assistant Professor Titu Maiorescu University of Bucharest, Faculty of General Nursing, Department of Molecular Biology, Branch City Targu Jiu, Romania Background P-53 Gene mutations are the most common genetic abnormalities of cancer. They have been extensively studied in various mature B cell malignancies, including Chronic Lymphocytic Leukemia, (CLL). In recent years, more attention has been paid to the importance of the p53 expressed protein in CLL, and a combination with low survival and non-response to classical conventional chemotherapy, due to mutations in the P-53 gene, with progression to Richter Syndrome. Identifying different P-53 gene mutations is very important because these mutations have an impact on patients' clinical course in CLL with the p-53 protein mutant isoform, [Photo 1]. Three dimensional shapes of the p-53 x ray protein structure in isomorphic form. Five genes P-53 mutations were identified in hereditary cancer clinics. A targeted mutation screen of cancer cases identified a c.844C>T [p. Arg-282-Trp] mutation carrier.
The aim of this paper was to highlight the stages of Chronic Lymphocytic Leukemia type B (CLL-B), which did not meet the standard treatment criteria for malignant hematological diseases due to mutations in the P-53 gene, with progression to Richter Syndrome. Method The frequency of p-53 protein expression in 85 patients diagnosed with CLL was analyzed by the Enzyme Linked Immune-Absorbent Assay (ELISA) technique to investigate the relationship of this protein to the stage of the disease, as well as the impact on response to treatment and survival. Cell extracts 10³×10³/L in 100 μl lysis buffer were applied to ELISA plates coated with PAb 240 capture antibody. Results The frequency of increased positivity of the protein with the modified structure, the isoform, p-53 in type B CLL, was 17% in the 85 cases initially included in the study. The percentage of p-53 protein isoforms, positive above normal value, with very high values, 50, 60, respectively 140 µg / dl was found in the percentage of 3.5% with the transformation of CLL into non-Hodgkin's malignant lymphomas, (NHL) type Diffuse Large Lymphoma, (DLL) or in Mantle Lymphoma, from Richter syndrome. Conclusions In the context of a heterogeneous condition such as LL-B, this cheap and safe method, ELISA seems to provide a useful prognostic tool capable of identifying patients who can be considered candidates for therapeutic, targeted, personalized strategies.
Editorial Note The book, Bioenergetics of the Normal and Malignant Cell, highlights the great necessity of Biological Sciences in medicine for progress in the pathophysiology of cancer diseases. The new volume provides their important milestones, studying the hematological and metabolic problems of the human body. The book details advance in cancer metabolism research over the past decade that have increased understanding of aerobic, anaerobic glycolysis, and other metabolic changes associated with cell growth and proliferation by altering cell signaling and blocking their differentiation in malignancies. The theoretical and practical work has an original content. It shows the great need for novelties in the biological sciences in general and in medicine, in particular, by specialists in the field, taking into account the progress in the pathophysiology and biochemistry of oncology throughout the years. The new book, recently published, can be of interest to doctors of all specialties, to medical students and to staff working in clinical laboratories, from different countries, presenting a large volume of data, experiences and laboratory research. in a systematic and logical display.
Rebecca Gladders, Senior Editor Operational headquarters in the Lady Stephenson Library, Newcastle upon Tyne, United Kingdom
Future new my Book which wil be published in Cambridge Publishing Cambridge, UK, has title : " Major Role of Mutant Gene P-53 and Isoform p-53 Protein in Hematologic Malignant Diseases ". Dr Aurel
RăspundețiȘtergereCurriculum Vitae
PERSONAL DETAILS:
First name: AURELIAN
Surname: UDRISTIOIU
Specialty: European Specialist in Laboratory Medicine
Age: 58
Gender: Male
Date of Birth: 05/11/1954
Citizenship: Romanian
Home Address: Traian Street, No: 26, City: Targu-Jiu, Romania
Telephone: 40723621414
Email Address: aurelianu2007@yahoo.com
Reason for applying to work abroad: Passion for works of researches in onco-hematology field
Available From (Month, Year): September / 2012
LANGUAGE SKILLS:
Language Level
ENGLISH 5
ITALIAN 5
RUSSIAN 4
ARABIC 3
MEDICAL AUTHORITY REGISTRATIONS:
Medical Authority Registration Number
License to practice in: EUROPEN UNION-EU
Certificate of Conformity, Number: NO. VIII. d / 55001 / 19. 10. 2007
BUCHAREST, ROMANIA.
Specialties: Internal Medicine, Oncology, Neurology, Emergency Medicine, Cardiology
No. of hospital beds: 1200
Outpatient services offered: Diagnostic Diseases, Treatments, Laboratory Investigation
Name and address of the hospital:
Emergency County Hospital TARGU-JIU,.Progresului Street No.18,Gorj, Postal Code:Zip 210218,Romania; Fax :00-40-253-210432 ;Phone :00-40-723621414, Romania.
- Manuscript 11-03-LM-U-MR-0052.R2/11/12/2011.
Journal of Medical Safety/September/2012, Tokio, Japan
Review of Applied Physics (RAP) Volume 2 Issue 1, March 2013; p-17-22
BC (Biochimica Clinica ), SS (Special Supplement), Volume 37, ISSN 0393-0564, Milan, Italy, 19-23 Mai 2013
Biophysical Journal, 2010.
WRITEN BOOKS:
1.Aurelian Udristioiu. “Fitness Bike and Health”. Ed. Medicala 1990, Bucuresti. ISBN: 973-39-01105-9; Formatul 16/10 x 100; Nr pagini: 78.
2.Aurelian Udristioiu. “Bioenergetics of malign and normal cells” Ed. Academica Brancusi 2002, Targu Jiu, Bun de tipar, Bucuresti, Tipografia Everest 2001; ISBN 973 85342-6-7; Formatul 16/14 x 100; Nr. Pagini: 307.
3. Aurelian Udristioiu, Manole Cojocaru, Radu Iliescu., “Hematological and Metabolic Aspects from Laboratory Medicine" (ISBN 978-3-8473-0775-4). LAP LAMBERT Academic Publishing GmbH & Co. KG Heinrich-Böcking-Str. 6-8 , 66121, Saarbrücken, Germany, 2012.
4. Book title: Renal Diseases / Book 2 (ISBN 979-953-307-704-7). Chapter title: Variability of Biological Parameters in Blood Samples between Two Consecutive Schedules of Hemodyalsis
Authors: Aurelian Udristioiu, Manole Cojocaru, Victor Dumitrascu, Daliborca Cristina Vlad, Alexandra Dana Maria Panait and Radu Iliescu, Publishing Group 2011.
Volume 2, Issue 4 (JULY 2011)
NATIONAL AND INTERNATIONAL AWARDS
- Aurelian Udristioiu. Anti-miocard Antibodies in Rheumatic Fever, Measured by Immunofluorescence, Medical Days, Craiova – May 1983. – Premium III Diploma.
- Aurelian Udristioiu. International Travel Grant AACC: Winner/56-th Annual Meeting AACC, 08/25-29/2004, Los Angeles, California, USA.
-Aurelian Udristioiu. International Travel Grant AACC, Winner/57-th Annual Meeting AACC, 07/24-28/2005, Orlando (FL), USA.
- Aurelian Udristioiu. Award: Clinical Chemist`s Recognition Award/2007-2008 and Award/2009, AACC, Washington al Society, since 2008, Columbus, (OH), USA..
-Aurelian Udristioiu, ‘ Who is Who in Romania/2009’ -Romanian Personality in Book Enciclopedy
-Aurelian Udristioiu. Award: Clinical Chemist`s Recognition Award/2007-2008 and Award/2009, AACC, Washington .
- Aurelian Udristioiu, ‘ Who is Who in medical departments USA/ 2011-2012: Who's Who in Medicine and Healthcare 2011-2012 (8th Edition)
” MarquisWho'sWho” , 300 ConnellDrive, Suite 2000, Berkeley Heights, N0: 07922 USA
1-908-673-1000 , www.marquiswhoswho.com
REFERENCES:
Name: Hospital: Contact phone number: Email address:
Manole Cojocaru
Titu Maiorescu University, Faculty of Medicine, Physiology Department, Bucharest, Romania; 0723326663 manole.cojocaru@yahoo.com
Dana Alexandra Maria Panait Titu Maiorescu University, Faculty of Medicine, Microbiology Department, Bucharest, Romania 0720949055 dana2pan@yahoo.com
My writer blog of medical Books.
RăspundețiȘtergereDr. Aurel
My presentation of Laboratoty Medicine Book with multiple researches in fundamental medical field.
RăspundețiȘtergereDr. Aurel
The Role of the P-53 Gene and the p-53 Protein in the Oncogenesis of Non-Hodgkin Malignant Lymphomas Aurelian Udristioiu, MD, Fellow PhD, Assistant Professor Titu Maiorescu University of Bucharest, Faculty of General Nursing, Department of Molecular Biology, Branch City Targu Jiu, Romania
RăspundețiȘtergereBackground
P-53 Gene mutations are the most common genetic abnormalities of cancer. They have been extensively studied in various mature B cell malignancies, including Chronic Lymphocytic Leukemia, (CLL). In recent years, more attention has been paid to the importance of the p53 expressed protein in CLL, and a combination with low survival and non-response to classical conventional chemotherapy, due to mutations in the P-53 gene, with progression to Richter Syndrome. Identifying different P-53 gene mutations is very important because these mutations have an impact on patients' clinical course in CLL with the p-53 protein mutant isoform,
[Photo 1].
Three dimensional shapes of the p-53 x ray protein structure in isomorphic form.
Five genes P-53 mutations were identified in hereditary cancer clinics. A targeted mutation screen of cancer cases identified a c.844C>T [p. Arg-282-Trp] mutation carrier.
The aim of this paper was to highlight the stages of Chronic Lymphocytic Leukemia type B (CLL-B), which did not meet the standard treatment criteria for malignant hematological diseases due to mutations in the P-53 gene, with progression to Richter Syndrome.
Method
The frequency of p-53 protein expression in 85 patients diagnosed with CLL was analyzed by the Enzyme Linked Immune-Absorbent Assay (ELISA) technique to investigate the relationship of this protein to the stage of the disease, as well as the impact on response to treatment and survival. Cell extracts 10³×10³/L in 100 μl lysis buffer were applied to ELISA plates coated with PAb 240 capture antibody.
Results
The frequency of increased positivity of the protein with the modified structure, the isoform, p-53 in type B CLL, was 17% in the 85 cases initially included in the study. The percentage of p-53 protein isoforms, positive above normal value, with very high values, 50, 60, respectively 140 µg / dl was found in the percentage of 3.5% with the transformation of CLL into non-Hodgkin's malignant lymphomas, (NHL) type Diffuse Large Lymphoma, (DLL) or in Mantle Lymphoma, from Richter syndrome.
Conclusions
In the context of a heterogeneous condition such as LL-B, this cheap and safe method, ELISA seems to provide a useful prognostic tool capable of identifying patients who can be considered candidates for therapeutic, targeted, personalized strategies.
Kaywords: Chronic Lymphocytic Leukaemia; P-53 gene; Intrinsic apoptosis; CD-5 receptor, Non-Hodgkin malignant lymphomas, Richter syndrome.
New book appearance
RăspundețiȘtergereBook, Bioenergetics of the normal and malignant cell, ISBN (10): 1-5275-9373-8; ISBN (13): 978-1-5275-9373-2. Pages 250. Copyright © 2023 by Aurelian Udriștioiu, Cambridge Scholars Publishing, Catalog available at the British Library, Great Britain.
Editorial Note
The book, Bioenergetics of the Normal and Malignant Cell, highlights the great necessity of Biological Sciences in medicine for progress in the pathophysiology of cancer diseases. The new volume provides their important milestones, studying the hematological and metabolic problems of the human body. The book details advance in cancer metabolism research over the past decade that have increased understanding of aerobic, anaerobic glycolysis, and other metabolic changes associated with cell growth and proliferation by altering cell signaling and blocking their differentiation in malignancies.
The theoretical and practical work has an original content. It shows the great need for novelties in the biological sciences in general and in medicine, in particular, by specialists in the field, taking into account the progress in the pathophysiology and biochemistry of oncology throughout the years. The new book, recently published, can be of interest to doctors of all specialties, to medical students and to staff working in clinical laboratories, from different countries, presenting a large volume of data, experiences and laboratory research. in a systematic and logical display.
Rebecca Gladders, Senior Editor
Operational headquarters in the Lady Stephenson Library, Newcastle upon Tyne, United Kingdom
Future new my Book which wil be published in Cambridge Publishing Cambridge, UK, has title : " Major Role of Mutant Gene P-53 and Isoform p-53 Protein in Hematologic Malignant Diseases ".
RăspundețiȘtergereDr Aurel